Cardiovascular Risk Factors and Disease Characteristics Are Consistently Associated with Arterial Function in Rheumatoid Arthritis
| Autor: | Patrick H Dessein, Linda Tsang, Chanel Robinson, Angela J. Woodiwiss, Aletta M.E. Millen, Gavin R. Norton, Sule Gunter |
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| Přispěvatelé: | Rheumatology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pulse Wave Analysis Immunology Hemodynamics Vascular Stiffness/physiology Blood Pressure Hemodynamics/physiology 030204 cardiovascular system & hematology Arthritis Rheumatoid 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Rheumatology Arthritis Rheumatoid/complications Internal medicine Arteries/physiopathology medicine Immunology and Allergy Rheumatoid factor Humans risk factors Cardiovascular Diseases/etiology Pulse wave velocity Blood Pressure/physiology Body mass index Aged 030203 arthritis & rheumatology business.industry Blood Flow Velocity/physiology Arteries Middle Aged medicine.disease Pulse pressure Surgery Reflection Magnitude Blood pressure Cardiovascular Diseases Arterial stiffness Cardiology Female business Blood Flow Velocity |
| Popis: | Objective.Arterial properties influence cardiovascular disease (CVD) risk. We identified potential determinants of arterial function in patients with rheumatoid arthritis (RA).Methods.Relationships of traditional cardiovascular risk factors and RA characteristics with arterial stiffness (pulse wave velocity), wave reflection (augmentation index, reflected wave pressure, and reflection magnitude), and pressure pulsatility (central systolic and pulse pressure, peripheral pulse pressure, pulse pressure amplification, and forward wave pressure) were identified in multivariable backward regression models among 177 patients without established CVD (118 white, 32 Asian, 22 black, 5 mixed ancestry).Results.Recorded characteristics explained 37% (pulse wave velocity) to 71% (reflected wave pressure) of the variability in arterial function. These factors were particularly associated with wave reflection and pressure pulsatility: RA duration (p = 0.04), rheumatoid factor status (p = 0.01 to 0.03), leukocyte counts (p = 0.02 to 0.05), and total cholesterol (p < 0.01 to 0.03). Body mass index (p < 0.01 to 0.02) and insulin resistance (p < 0.01 to 0.01) were related to reduced wave reflection and peripheral pulse pressure. Exercise (p = 0.02) and alcohol consumption (p < 0.01) were associated with increased pulse pressure amplification and decreased peripheral pulse pressure, respectively. Tumor necrosis factor-α inhibition (p < 0.01) was related to reduced pulse wave velocity, and tetracycline use (p = 0.02) to decreased peripheral pulse pressure.Conclusion.Traditional cardiovascular risk factors and disease characteristics are consistently associated with vascular hemodynamic alterations in RA. The relative effect of arterial stiffness, wave reflection, and pressure pulsatility on CVD risk in RA needs further study. |
| Databáze: | OpenAIRE |
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