Introduction and prolonged circulation of G12 rotaviruses in Sicily
| Autor: | Floriana Bonura, D. M. Terranova, Vito Martella, F. Di Bernardo, Krisztián Bányai, M. Palermo, G. Ferrera, M. T. Allù, Mariella Valenzise, Antonio Cascio, P. Dones, A. Collura, Laura Saporito, Giovanni M. Giammanco, S. De Grazia, N. Casuccio |
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| Přispěvatelé: | Giammanco, G., Bonura, F., Di Bernardo, F., Cascio, A., Ferrera, G., Dones, P., Saporito, L., Collura, A., Terranova, D., Valenzise, M., Allù, M., Casuccio, N., Palermo, M., Bányai, K., Martella, V., De Grazia, S. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Veterinary medicine Settore MED/07 - Microbiologia E Microbiologia Clinica Adolescent Genotype Settore MED/17 - Malattie Infettive Epidemiology viruses Rotavirus Infections Biology medicine.disease_cause Feces 03 medical and health sciences Rotavirus Prevalence medicine Cluster Analysis Humans Cities G12 Child Antigens Viral Sicily Phylogeny virus diseases Infant Sequence Analysis DNA rotavirus Acute gastroenteritis Original Papers language.human_language Gastroenteritis Rotavirus infection 030104 developmental biology Infectious Diseases Child Preschool language Capsid Proteins Female Sicilian |
| Zdroj: | Epidemiol Infect |
| Popis: | SUMMARYGenotype G12 strains are now considered to be the sixth most prevalent human rotaviruses worldwide. In two Sicilian cities, Palermo and Messina, surveillance of rotavirus circulation performed since 1985 and 2009, respectively, did not detect G12 strains until 2012. From 2012 to 2014 rotavirus infection was detected in 29·7% of 1647 stool samples collected from children admitted for acute gastroenteritis to three Sicilian hospitals in Palermo, Messina and Ragusa. In 2012, G12P[8] was first detected in Palermo and then in Messina where it represented the second most frequent genotype (20% prevalence) after G1P[8]. Thereafter, G12 strains continued to circulate in Sicily, showing a marked prevalence in Ragusa (27·8%) in 2013 and in Palermo (21%) and Messina (16·6%) in 2014. All but one of the Sicilian G12 strains carried a P[8] VP4 genotype, whereas the single non-P[8] rotavirus strain was genotyped as G12P[9]. Phylogenetic analysis of the VP7 and VP4 sequences allowed distinction of several genetic lineages and separation of the G12P[8] strains into three cluster combinations. These findings indicate independent introductions of G12 rotavirus strains in Sicily in recent years. |
| Databáze: | OpenAIRE |
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