A Comparison of Botox 100 U/mL and Dysport 100 U/mL Using Dose Conversion Ratio 1
| Autor: | Alma Rystedt, Lena Zetterberg, Dag Nyholm, Joachim Burman, Anders Johansson |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Injections Intramuscular Severity of Illness Index law.invention Double blind Double-Blind Method Randomized controlled trial law medicine Humans Pharmacology (medical) Cervical dystonia Botulinum Toxins Type A Torticollis Aged Aged 80 and over Pharmacology Cross-Over Studies Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Crossover study Anesthesia Female Neurology (clinical) Nuclear medicine business Dose conversion |
| Zdroj: | Clinical Neuropharmacology. 38:170-176 |
| ISSN: | 0362-5664 |
| DOI: | 10.1097/wnf.0000000000000101 |
| Popis: | Intramuscular injections of botulinum toxin (BTX) are used as symptomatic treatment for cervical dystonia. Botox and Dysport are commercial products containing BTX; however, dosage and concentration of the prepared solution vary considerably among studies. The concentration of BTX in the prepared solution affects clinical outcome. This double-blind, randomized crossover trial compares Botox and Dysport in 2 different dose conversion ratios (1:3 and 1:1.7) when diluted to the same concentration (100 U/mL).Forty-six patients with cervical dystonia received 3 different treatments, Botox in 2 different doses and Dysport as control treatment. The efficacy was evaluated 4 and 12 weeks after treatment using 5 instruments, including Toronto Western Spasmodic Torticollis Rating Scale.The primary outcome was the estimated median Toronto Western Spasmodic Torticollis Rating Scale total score, which was 1.96 points higher for Botox (1:3) compared with Dysport at week 4, but the difference was not statistically significant (confidence interval, -0.88-4.61; P = 0.0799). No significant differences were seen between Botox (1:1.7) and Dysport. At week 12, a statistically significant difference in effect between Botox (1:3) and Dysport was observed, suggesting a shorter duration of effect for Botox when this ratio (low dose) was used. Furthermore, the patients' assessments showed that the ratio 1:3 resulted in suboptimal efficacy of Botox. These secondary outcome observations indicate that the dose conversion ratio between Dysport 100 U/mL and Botox 100 U/mL may be lower than 1:3, but this must be further validated in a larger patient material. |
| Databáze: | OpenAIRE |
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