Development and validation of a staging system for gastric adenocarcinoma after neoadjuvant chemotherapy and gastrectomy with D2 lymphadenectomy
Autor: | Chang Hwan Yoon, Jacopo Desiderio, Jian-Xian Lin, Chang Ming Huang, A Parisi, Brendan C. Yi, Ping Li, Vivian E. Strong, S S Yoon, Chao-Hui Zheng |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Kaplan-Meier Estimate Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Gastrectomy Stomach Neoplasms medicine Humans 030212 general & internal medicine Neoadjuvant therapy Survival analysis Neoplasm Staging Chemotherapy Receiver operating characteristic business.industry Reproducibility of Results Cancer Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Neoadjuvant Therapy 030220 oncology & carcinogenesis Cohort Lymph Node Excision Female Surgery Lymphadenectomy Radiology business |
Zdroj: | British Journal of Surgery. 106:1187-1196 |
ISSN: | 1365-2168 0007-1323 |
Popis: | Background Neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy is commonly used for patients with locally advanced gastric adenocarcinoma. The eighth AJCC ypTNM staging system was validated based on patients undergoing more limited lymphadenectomy (less than D2). The aim of this study was to develop a system for accurate staging of patients with locally advanced gastric adenocarcinoma who receive neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy. Methods A modified system of ypTNM was developed, based on overall survival (OS) of patients receiving neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy at Memorial Sloan Kettering Cancer Center, and validated using data from an international cohort of patients who had similar treatment. Results Of 325 patients in the derivation cohort, 33 (10·2 per cent) had ypT0 N0/+ tumours, which are not classifiable under the AJCC system. The 5-year OS rate for modified ypTNM stages I, II, IIIA and IIIB was 89, 71, 42·3 and 10 per cent respectively, compared with 82, 65·2 and 24·1 for AJCC stages I, II and III respectively. The concordance index (0·730 versus 0·709), estimated area under the curve (0·765 versus 0·740) and time-dependent receiver operating characteristic (ROC) curve throughout the observation period were all superior for modified ypTNM staging. For the validation cohort of 186 patients, the modified system was again better at separating patients into prognostic groups for OS. Conclusion The modified ypTNM staging system improves the accuracy of OS prediction for patients treated with neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy. |
Databáze: | OpenAIRE |
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