Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus
| Autor: | Stefan Jovinge, Audrey Niemann, Hans Lithell, Jan Nilsson, Richard Reneland |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Aging medicine.medical_specialty medicine.medical_treatment Glucose uptake Adipose tissue Enzyme-Linked Immunosorbent Assay Body Mass Index Insulin resistance Internal medicine Diabetes mellitus Blood plasma medicine Humans Obesity Aged Sweden Analysis of Variance Glucose tolerance test medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Insulin Glucose Tolerance Test medicine.disease Lipids Endocrinology Diabetes Mellitus Type 2 Tumor necrosis factor alpha Insulin Resistance Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 18:1199-1202 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.18.8.1199 |
| Popis: | Abstract —Human obesity is associated with an increased tumor necrosis factor-α (TNF-α) mRNA expression in adipose tissue. TNF-α decreases insulin-dependent glucose uptake by inhibiting autophosphorylation of the insulin receptor, suggesting that TNF-α may play a role in insulin resistance. In this study, we analyzed plasma levels of TNF-α in 40 70-year-old men with newly detected non–insulin-dependent diabetes mellitus and in 20 age-matched controls. Twenty of the patients had a moderate level of insulin resistance and 20 were severely insulin resistant. The plasma levels of TNF-α were higher in patients (4.00±1.53 pg/mL in moderately insulin resistant and 4.91±1.43 pg/mL in severely insulin resistant subjects) than in controls (3.27±0.79 pg/mL, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|