The Effect of Local Use of Nandrolone Decanoate on Rotator Cuff Repair in Rabbits

Autor:	Kleo Papaparaskeva, John Feroussis, Athanasios Papaspiliopoulos, Aristedes Zoubos, Apostolos Papalois, Eleni Papadopoulou
Rok vydání:	2010
Předmět:	Male Restraint Physical medicine.medical_specialty Anabolism medicine.medical_treatment Connective tissue Anabolic Agents Steroid Tendons Rotator Cuff medicine Animals Nandrolone Rotator cuff Wound Healing business.industry Recovery of Function Biomechanical Phenomena Tendon Surgery medicine.anatomical_structure Nandrolone Decanoate Models Animal Rabbits business Anabolic steroid medicine.drug
Zdroj:	Journal of Investigative Surgery. 23:204-207
ISSN:	1521-0553 0894-1939
DOI:	10.3109/08941939.2010.481007
Popis:	There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair.Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation.Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids.The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor.
Databáze:	OpenAIRE
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