Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

Autor:	Keiji Shitsukawa, Mayumi Sugimoto, Hiroshi Kido, Kokichi Arisawa, Shoji Kagami, Limin Yang, Yukiko Ogawa, Hirohisa Saito, Yukihiro Ohya, Kenji Kubota, Wakako Shinahara, Makoto Irahara
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male 0301 basic medicine Eggs Antibody Affinity Immunoglobulin E low‐affinity immunoglobulin E 0302 clinical medicine Antibody Specificity Pregnancy Lactation Immunology and Allergy Original Research Age Factors allergen microarray Isotype Immunoglobulin Isotypes Milk medicine.anatomical_structure Cord blood Female eczema Antibody lcsh:Immunologic diseases. Allergy Immunology Biology immunoglobulin isotype formation 03 medical and health sciences Food allergy medicine Animals Humans high‐affinity immunoglobulin E Egg Hypersensitivity food allergy Infant Newborn Infant Allergens medicine.disease Immunoglobulin Class Switching Ovalbumin 030104 developmental biology Immunoglobulin class switching Antibody Formation biology.protein Cattle Milk Hypersensitivity lcsh:RC581-607 Chickens 030215 immunology
Zdroj:	Immunity, Inflammation and Disease, Vol 7, Iss 2, Pp 74-85 (2019) Immunity, Inflammation and Disease
ISSN:	2050-4527
Popis:	Introduction Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type‐related egg‐ and milk‐specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Methods Allergen‐specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Results Formula and mixed feeding were associated with a rapid increase in cow's milk allergen‐specific immunoglobulins and feeding type‐related significant differences in casein‐specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin‐specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low‐ or high‐affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin‐specific IgG1 levels, detectable IgG2, and low‐affinity IgE, while the other had low ovalbumin‐specific IgG1 levels, undetectable IgG2, and high levels of high‐affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Conclusions Feeding practice‐related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high‐affinity IgE.
Databáze:	OpenAIRE
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