Zinc-fortified oral rehydration solution improved intestinal permeability and small intestinal mucosal recovery
| Autor: | Geoffrey P. Davidson, Cuong D. Tran, Ross N. Butler, Erin L. Symonds, Robin D. Graham, Joanna S. Hawkes, Julie L. Kitchen |
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| Přispěvatelé: | Tran, Cuong D, Hawkes, Joanna, Graham, Robin D, Kitchen, Julie L, Symonds, Erin L, Davidson, Geoffrey P, Butler, Ross N |
| Rok vydání: | 2014 |
| Předmět: |
Male
zinc-fortified oral rehydration solution medicine.medical_specialty Cell Membrane Permeability Rhamnose chemistry.chemical_element Zinc Gastroenterology Lactulose chemistry.chemical_compound Double-Blind Method Internal medicine Intestine Small medicine Humans Intestinal Mucosa Child Breath test Intestinal permeability medicine.diagnostic_test intestinal permeability sucrose breath test business.industry Infant diarrheal disease medicine.disease Surgery Gastroenteritis Intestines chemistry Breath Tests Intestinal Absorption Child Preschool Rehydration Solutions Pediatrics Perinatology and Child Health Female Diarrheal disease business medicine.drug |
| Zdroj: | Clinical pediatrics. 54(7) |
| ISSN: | 1938-2707 |
| Popis: | A randomized double-blind placebo-controlled study was conducted in children admitted to hospital with gastroenteritis (≥3 loose stools per day). All were treated for 5 days following admission with either zinc (Zn, 3 mg) or without Zn-fortified rice-based oral rehydration solution (ORS). 13C-sucrose breath test (SBT) and intestinal permeability (lactulose/rhamnose or L/R ratio) were performed concurrently prior to commencement of ORS with or without Zn and at day 5 post-admission. There was a significant improvement in the SBT results in both the Zn-fortified group, median (5th-95th percentile) 2.1% (0.4% to 8.3%) versus 4.4% (0.4% to 10.4%), P < .05, and control group, 1.4% (0.1% to 5.4%) versus 4.3% (0.4% to 11.4%), P < .05, between the day of admission and day 5 post-admission. In the Zn-fortified group, there was also a significant improvement in L/R ratio between the day of admission and day 5 post-admission, 53.0 (19.5-90.6) versus 17.7 (13.4-83.2), P < .05. Low levels of Zn improved intestinal permeability but did not enhance short-term recovery following diarrheal illness. |
| Databáze: | OpenAIRE |
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