Physician clinical decision support system prompts and administration of subsequent doses of HPV vaccine: A randomized clinical trial
Autor: | Tamara M. Dugan, Gregory D. Zimet, Brianna Lindsay, Wanzhu Tu, Abby Church, Tracey A. Wilkinson, Stephen M. Downs, Meena Sheley, Shan Xiao, Brian E. Dixon |
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Rok vydání: | 2019 |
Předmět: |
Data Analysis
Male medicine.medical_specialty Adolescent Health Personnel HPV vaccines Logistic regression Clinical decision support system law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics Internal medicine Statistical significance Odds Ratio medicine Electronic Health Records Humans Papillomavirus Vaccines 030212 general & internal medicine Practice Patterns Physicians' Child Generalized estimating equation General Veterinary General Immunology and Microbiology business.industry Papillomavirus Infections Vaccination Public Health Environmental and Occupational Health Decision Support Systems Clinical United States Clinical trial Infectious Diseases Molecular Medicine Female business |
Zdroj: | Vaccine. 37:4414-4418 |
ISSN: | 0264-410X |
Popis: | Background HPV vaccine is effective in preventing several cancers and anogenital warts, yet rates of HPV vaccination series completion in the United States are low. A primary reason identified by parents for vaccinating children against HPV is a health care provider’s recommendation. Although most clinicians embrace vaccine recommendations, they are not always carried out evenly and subsequent HPV vaccines are missed. Methods Using an electronic health records-based decision support system (CHICA) clinicians were randomized to either usual practice or to receive an automated reminder to recommend the 2nd or 3rd dose of HPV vaccine. The reminder was delivered to clinicians of all intervention group eligible adolescents who had already initiated the vaccine series. Logistic regression models with generalized estimating equations were used for data analysis. Results A total of 1285 clinical encounters were observed across 29 randomized pediatric providers over a 13-month time frame (50.7% control group, 49.3% intervention group). Overall, patients were 44.9% female, 59.4% Black, 22.1% Hispanic, and 48.8% were ages 11–12 yrs. Within the control group, 421 (64.7%) received a subsequent HPV vaccine, compared to 481 (75.9%) (OR: 1.72, (95% CI 1.35–2.19)). Adjusted analysis showed no difference between the groups (aOR 1.52 (95% CI 0.88–2.62)) or when examined by age (11-12yrs aOR 1.66, (95% CI 0.79–3.48)) and 13-17yrs (aOR 1.19, (95% CI 0.76–1.85)) or gender female (aOR 1.39 (95% CI 0.71–2.72)) and males (aOR 1.67 (95% CI 0.95–2.92)). When results were stratified by both age and gender, there was similarly no statistically significant effect between the two groups. Conclusions Automated physician reminders for subsequent 2nd and 3rd doses of HPV vaccination were used. Despite increased rates of vaccination in the intervention group, the differences did not reach the level of statistical significance. Future studies with multifaceted approaches may be needed to examine the efficacy of computer-based reminders. Clinical Trial Registration: NCT02558803, “HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3”. |
Databáze: | OpenAIRE |
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