Intracranial mast cells contribute to the control of social behavior in male mice
| Autor: | Hiroyoshi Sei, Noriyuki Shimizu, Daisuke Tanioka, Sachiko Chikahisa, Noriaki Sakai, Tetsuya Shiuchi, Seiji Nishino |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Cell Male mice Biology 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Mice 0302 clinical medicine Emotionality Internal medicine medicine Animals p-Methoxy-N-methylphenethylamine Mast Cells Social Behavior 5-HT receptor 030304 developmental biology Mice Knockout 0303 health sciences Behavior Animal Brain Compound 48/80 Mast cell Oxytocin receptor humanities Mice Inbred C57BL medicine.anatomical_structure Endocrinology chemistry Receptors Serotonin 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 403 |
| ISSN: | 1872-7549 |
| Popis: | Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain. |
| Databáze: | OpenAIRE |
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