Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography
| Autor: | Matt Carré, Michael J. Cork, Bethany Mitchell, Roger Lewis, Raman Maiti, Elaine J. Pang, Simon G. Danby, Robert A. Byers, Stephen J. Matcher |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Plexus
medicine.medical_specialty medicine.diagnostic_test business.industry Atopic dermatitis medicine.disease 01 natural sciences Atomic and Molecular Physics and Optics Article Muscle hypertrophy 010309 optics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Optical coherence tomography 0103 physical sciences Sub clinical Biomarker (medicine) Medicine In patient Radiology business Biotechnology Subclinical infection |
| Popis: | Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of sub-clinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust biomarker for quantifying the severity of clinical and sub-clinical AD. To investigate this, angiographic data sets were acquired from 32 patients with a range of AD severities. Deeper vascular layers within skin were found to correlate with increasing clinical severity. Furthermore, for AD patients exhibiting no clinical symptoms, the superficial plexus depth was found to be significantly deeper than healthy patients at both the elbow (p = 0.04) and knee (p |
| Databáze: | OpenAIRE |
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