Human DHHC proteins: a spotlight on the hidden player of palmitoylation
| Autor: | Dżamila M. Bogusławska, Aleksander F. Sikorski, Agnieszka Łach, Marcin Wolny, Katarzyna Augoff, Monika Toporkiewicz, Elżbieta Heger, Justyna Korycka, Jan Korzeniewski |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Histology
Lipoylation Palmitic Acid Gene Expression Cell Biology General Medicine Biology Pathology and Forensic Medicine Structure and function Cell biology Isoenzymes Alternative Splicing Mice Palmitoylation Organ Specificity Databases Genetic Animals Humans Protein palmitoylation Gene Protein Processing Post-Translational Acyltransferases Phylogeny |
| Zdroj: | European journal of cell biology. 91(2) |
| ISSN: | 1618-1298 |
| Popis: | Palmitoylation is one of the most common posttranslational lipid modifications of proteins and we now know quite a lot about it. However, the state of knowledge about the enzymes that catalyze this process is clearly insufficient. This review is focused on 23 human DHHC genes and their products – protein palmitoyltransferases. Here we describe mainly the structure and function of these proteins, but also, to a lesser degree, what the substrates of the enzymes are and whether they are related to various diseases. The main aim of this review was to catalogue existing information concerning the human DHHC family of genes/proteins, making them and their functions easier to understand. |
| Databáze: | OpenAIRE |
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