Topical glucocorticoids and suppression of contact sensitivity. A mouse bioassay of anti-inflammatory effects
| Autor: | O. Bäck, Torbjörn Egelrud |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone medicine.drug_class Administration Topical medicine.medical_treatment Anti-Inflammatory Agents Dose-Response Relationship Immunologic Human skin Picryl Chloride Dermatology Dermatitis Contact Anti-inflammatory Steroid Picryl chloride Mice chemistry.chemical_compound Internal medicine otorhinolaryngologic diseases medicine Animals Ear External Glucocorticoids Clobetasol business.industry Mice Inbred C57BL Disease Models Animal Dose–response relationship Endocrinology chemistry Mice Inbred CBA Biological Assay sense organs business Glucocorticoid medicine.drug Topical steroid |
| Zdroj: | British Journal of Dermatology. 112:539-545 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1985.tb15261.x |
| Popis: | A mouse model for assessment of the anti-inflammatory effect of topical glucocorticoids is described. Mice, sensitized to picryl chloride, had both ears painted with the sensitizer followed 2 hours later by the application of the topical steroid to one ear and the corresponding vehicle to the other. The contact sensitivity reaction, measured by swelling of the ear, was recorded 24 hours later. Dilutions of the steroid formulations inhibited the ear swelling in a manner related to dose-response. Suppression of the contact sensitivity reaction of the vehicle-treated ear as well was regarded as a systemic effect of the glucocorticoid. There seems to be a good correlation between the efficacy of the topical steroids assessed in this mouse model and the vasoconstrictor test on intact human skin. |
| Databáze: | OpenAIRE |
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