Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators
| Autor: | Iñigo Azcoitia, Luis M. Garcia-Segura, Estefania Acaz-Fonseca, Rebeca Sánchez-González, María Ángeles Arévalo |
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| Rok vydání: | 2013 |
| Předmět: |
Selective Estrogen Receptor Modulators
medicine.medical_specialty Neuroglobin Estrogen receptor Biochemistry Neuroprotection Endocrinology Neuroinflammation Neurotrophic factors Internal medicine medicine Animals Humans Molecular Biology Neurons Glutamate transporters Estradiol business.industry Glutamate receptor Brain Estrogens Neuroprotective Agents Gliosis Receptors Estrogen Selective estrogen receptor modulator Astrocytes Brain edema Reactive astrocytes medicine.symptom business GPER hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1872-8057 |
| Popis: | Neuroprotective actions of 17β-estradiol (estradiol) are in part mediated by direct actions on neurons. Astrocytes, which play an essential role in the maintenance of the homeostasis of neural tissue, express estrogen receptors and are also involved in the neuroprotective actions of estradiol in the brain. Estradiol controls gliosis and regulates neuroinflammation, edema and glutamate transport acting on astrocytes. In addition, the hormone regulates the release of neurotrophic factors and other neuroprotective molecules by astrocytes. In addition, reactive astrocytes are a local source of neuroprotective estradiol for the injured brain. Since estradiol therapy is not free from peripheral risks, alternatives for the hormone have been explored. Some selective estrogen receptor modulators (SERMs), which are already in use in clinical practice for the treatment of breast cancer, osteoporosis or menopausal symptoms, exert similar actions to estradiol on astrocytes. Therefore, SERMs represent therapeutic alternatives to estradiol for the activation of astroglia-mediated neuroprotective mechanisms. © 2014 Elsevier Ireland Ltd. |
| Databáze: | OpenAIRE |
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