Individual Postprandial Glycemic Responses to Diet in n-of-1 Trials: Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)
| Autor: | Min Yang, Yunyi Tian, Zelei Miao, Wanglong Gou, Ju-Sheng Zheng, Yuanqing Fu, Jose M. Ordovas, Yue Ma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose N of 1 trial Medicine (miscellaneous) Physiology 030209 endocrinology & metabolism Eating Young Adult 03 medical and health sciences Human health 0302 clinical medicine Dietary Carbohydrates Humans Medicine 030212 general & internal medicine Total energy Diet Fat-Restricted Glycemic Nutrition and Dietetics Continuous glucose monitoring business.industry Blood Glucose Self-Monitoring Chinese adults Bayes Theorem Postprandial Period Dietary Fats Postprandial Female business |
| Zdroj: | The Journal of Nutrition. 151:3158-3167 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxab227 |
| Popis: | Background The role of different types and quantities of macronutrients on human health has been controversial, and the individual response to dietary macronutrient intake needs more investigation. Objectives We aimed to use an 'n-of-1' study design to investigate the individual variability in postprandial glycemic response when eating diets with different macronutrient distributions among apparently healthy adults. Methods Thirty apparently healthy young Chinese adults (women, 68%) aged between 22 and 34 y, with BMI between 17.2 and 31.9 kg/m2, were provided with high-fat, low-carbohydrate (HF-LC, 60-70% fat, 15-25% carbohydrate, 15% protein, of total energy) and low-fat, high-carbohydrate (LF-HC, 10-20% fat, 65-75% carbohydrate, 15% protein) diets, for 6 d wearing continuous glucose monitoring systems, respectively, in a randomized sequence, interspersed by a 6-d wash-out period. Three cycles were conducted. The primary outcomes were the differences of maximum postprandial glucose (MPG), mean amplitude of glycemic excursions (MAGE), and AUC24 between intervention periods of LF-HC and HF-LC diets. A Bayesian model was used to predict responders with the posterior probability of any 1 of the 3 outcomes reaching a clinically meaningful difference. Results Twenty-eight participants were included in the analysis. Posterior probability of reaching a clinically meaningful difference of MPG (0.167 mmol/L), MAGE (0.072 mmol/L), and AUC24 (13.889 mmol/L·h) between LF-HC and HF-LC diets varied among participants, and those with posterior probability >80% were identified as high-carbohydrate responders (n = 9) or high-fat responders (n = 6). Analyses of the Bayesian-aggregated n-of-1 trials among all participants showed a relatively low posterior probability of reaching a clinically meaningful difference of the 3 outcomes between LF-HC and HF-LC diets. Conclusions N-of-1 trials are feasible to characterize personal response to dietary intervention in young Chinese adults. |
| Databáze: | OpenAIRE |
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