Effects of trichothecene mycotoxin T-2 toxin on haematological and immunological parameters of rainbow trout (Oncorhynchus mykiss)
| Autor: | Jan Mareš, Jana Blahova, Helena Modra, Jana Bartonkova, Miroslava Palíková, Pavel Hyršl, Ivana Papezikova, Zdenka Svobodova |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lymphocyte Neutrophil granulocyte Food Contamination Toxicology medicine.disease_cause 01 natural sciences Microbiology Hemoglobins Leukocyte Count 03 medical and health sciences Immune system Fusarium Internal medicine medicine Animals Mean corpuscular volume 0303 health sciences biology medicine.diagnostic_test Chemistry Toxin 030302 biochemistry & molecular biology 010401 analytical chemistry Animal Feed Immunity Humoral 0104 chemical sciences T-2 Toxin medicine.anatomical_structure Endocrinology Oncorhynchus mykiss Humoral immunity Erythrocyte Count biology.protein Rainbow trout Antibody Biotechnology |
| Zdroj: | Mycotoxin Research. 36:319-326 |
| ISSN: | 1867-1632 0178-7888 |
| Popis: | The aim of this study was to assess the effects of T-2 toxin-contaminated feed (at concentrations of 1.0 and 1.8 mg/kg) on the rainbow trout immune system by studying non-specific cellular and humoral immune responses and its effect on red and white blood cells. Consumption of T-2 toxin at both concentrations resulted in significantly increased erythrocyte counts and a decrease in mean corpuscular volume. While a significant decrease in mean corpuscular haemoglobin was observed at both experimental concentrations, the decrease in plasma haemoglobin was only significant at the higher T-2 toxin concentration. Higher T-2 toxin concentrations resulted in a significant increase in leukocyte and lymphocyte count, while absolute phagocyte count and counts of less mature neutrophil granulocyte forms remained unchanged at both concentrations. Non-specific humoral immunity (bactericidal activity measured as complement activation) decreased significantly in both experimental groups when compared with the control. The results of this study show that T-2 toxin in feed at a concentration range of 1.0-1.8 mg/kg influences the immunological defence mechanisms of rainbow trout.Trial registration number, MSMT-3876/2014-14; date of registration, 31/1/2014. |
| Databáze: | OpenAIRE |
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