The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome

Autor: Elizabeth V. Saarel, Robert L. Lux, Christopher Todd Sower, Susan P. Etheridge, Martin Tristani-Firouzi, Nancy A. Allen
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Anatomy and Physiology
genetic structures
Moxifloxacin
lcsh:Medicine
Arrhythmias
Cardiovascular
Pediatrics
Root mean square
Heart Rate
Pediatric Cardiology
Child
lcsh:Science
Randomized Controlled Trials as Topic
Multidisciplinary
medicine.diagnostic_test
Middle Aged
Electrophysiology
Long QT Syndrome
Child
Preschool
Data Interpretation
Statistical
Cardiology
Medicine
Female
Fluoroquinolones
Research Article
Test Evaluation
Adult
medicine.medical_specialty
Drugs and Devices
Cardiotonic Agents
Adolescent
Long QT syndrome
QT interval
Ventricular action potential
Medical Devices
QRS complex
Young Adult
Diagnostic Medicine
Internal medicine
T wave
medicine
Repolarization
Humans
cardiovascular diseases
Biology
business.industry
Acute Cardiovascular Problems
lcsh:R
medicine.disease
Case-Control Studies
Electrocardiography
Ambulatory
lcsh:Q
business
Electrocardiography
Zdroj: PLoS ONE, Vol 9, Iss 1, p e85689 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: BACKGROUND: Precise measurement of the QT interval is often hampered by difficulty determining the end of the low amplitude T wave. Root mean square electrocardiography (RMS ECG) provides a novel alternative measure of ventricular repolarization. Experimental data have shown that the interval between the RMS ECG QRS and T wave peaks (RTPK) closely reflects the mean ventricular action potential duration while the RMS T wave width (TW) tracks the dispersion of repolarization timing. Here, we tested the precision of RMS ECG to assess ventricular repolarization in humans in the setting of drug-induced and congenital Long QT Syndrome (LQTS). METHODS: RMS ECG signals were derived from high-resolution 24 hour Holter monitor recordings from 68 subjects after receiving placebo and moxifloxacin and from standard 12 lead ECGs obtained in 97 subjects with LQTS and 97 age- and sex-matched controls. RTPK, QTRMS and RMS TW intervals were automatically measured using custom software and compared to traditional QT measures using lead II. RESULTS: All measures of repolarization were prolonged during moxifloxacin administration and in LQTS subjects, but the variance of RMS intervals was significantly smaller than traditional lead II measurements. TW was prolonged during moxifloxacin and in subjects with LQT-2, but not LQT-1 or LQT-3. CONCLUSION: These data validate the application of RMS ECG for the detection of drug-induced and congenital LQTS. RMS ECG measurements are more precise than the current standard of care lead II measurements.
Databáze: OpenAIRE
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