A closer look at pathogenesis of cerebral mucormycosis in diabetic condition: A mini review
| Autor: | Fateme Taheri, Amin Khoshbayan, Mojtaba Didehdar, Aref Shariati, Zahra Chegini |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mucorales
Pediatrics medicine.medical_specialty Diabetic ketoacidosis Iron Disease Eye Applied Microbiology and Biotechnology Diabetic Ketoacidosis Mini review Diabetes Complications Pathogenesis 03 medical and health sciences Diabetes mellitus medicine Humans Mucormycosis 030304 developmental biology 0303 health sciences biology 030306 microbiology business.industry General Medicine biology.organism_classification medicine.disease Acquired immune system Diabetes Mellitus Type 1 Rhizopus oryzae business |
| Zdroj: | Journal of Basic Microbiology. 61:212-218 |
| ISSN: | 1521-4028 0233-111X |
| DOI: | 10.1002/jobm.202000692 |
| Popis: | Patients with diabetes are considered a high-risk group involved with cerebral mucormycosis (CM). Due to the potential of Mucorales to invade sinuses and its rapid progression into orbit and retro-orbital areas and even brain, in most cases, CM is fatal in patients with diabetes. In the last few decades, mucormycosis and background conditions responsible for the development of its infections have received a great deal of attention. Dysfunction of innate and adaptive immune system, the increased amount of available nutrition, expression of host factors, and free iron level in plasma in diabetic ketoacidosis are among the topics that have been mostly taken into account so far. Therefore, it is important to clarify the molecular mechanisms that let the Mucorales to involve the patients with diabetes, which even at early stages of diagnosis and treatment, there is minimum chance to control the disease. |
| Databáze: | OpenAIRE |
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