Tract-Specific Diffusion Tensor Imaging Reveals Laterality of Neurological Symptoms in Patients with Cervical Compression Myelopathy
| Autor: | Sho Takahashi, Koji Matsumoto, Mitsutoshi Ota, Masashi Yamazaki, Taigo Inada, Yasushi Iijima, Yoshitada Masuda, Kazuhisa Takahashi, Junya Saito, Masao Koda, Takayuki Obata, Koshiro Kamiya, Satoshi Maki, Takeo Furuya, Masatoshi Kojima |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Functional Laterality Statistics Nonparametric 030218 nuclear medicine & medical imaging 03 medical and health sciences Myelopathy 0302 clinical medicine Fractional anisotropy medicine Humans Decision Making Computer-Assisted Aged Cervical Plexus Arthrogryposis Neurologic Examination medicine.diagnostic_test business.industry Cervical plexus Extremities Magnetic resonance imaging Middle Aged medicine.disease Spinal cord Magnetic Resonance Imaging Surgery Diffusion Tensor Imaging medicine.anatomical_structure Spinal Cord Corticospinal tract Laterality Anisotropy Female Neurology (clinical) Radiology Hereditary Sensory and Motor Neuropathy business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | World Neurosurgery. 96:184-190 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2016.08.129 |
| Popis: | Patients with cervical compression myelopathy (CCM) generally present bilateral neurological symptoms in their extremities. However, a substantial portion of patients with CCM exhibit laterality of neurological symptoms. The aim of this study was to assess the correlation between intrinsic structural damage and laterality of symptoms using spinal cord diffusion tensor imaging (DTI) of the corticospinal tract.We enrolled 10 healthy volunteers and 40 patients with CCM in this study. We evaluated motor function using the American Spinal Injury Association (ASIA) motor score for left and right extremities. For DTI acquisitions, a 3.0-T magnetic resonance imaging system with diffusion-weighted spin-echo sequence was used. Regions-of-interest in the lateral column tracts were determined. We determined the correlations between fractional anisotropy (FA) and ASIA motor scores. An FA asymmetry index was calculated using left and right regions-of-interest.Four patients exhibited laterality of symptoms in their extremities, for which left and right ASIA scores correlated moderately with FA in the left and right lateral columns, respectively (left: ρ = 0.64, P0.001; right: ρ = 0.67, P0.001). The area under the receiver-operator characteristic curve showed that the FA asymmetry index indicated laterality of symptoms.Using tract-specific DTI, we demonstrated that microstructural damages in the left and right corticospinal tracts correlated with corresponding neurological symptoms in the ipsilateral side and the FA asymmetry index could indicate laterality in neurological symptoms of patients with CCM. |
| Databáze: | OpenAIRE |
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