Comparative decorporation efficacy of 3,4,3-LIHOPO, 4,4,4-LIHOPO and DTPA after contamination of rats with soluble forms of 238Pu and 233U
| Autor: | G. Grillon, G. Rataeu, B. Ramounet-Le Gall, T. Bailly, R. Burgada, P. Fritsch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Dose Pyridones Whole-Body Counting Excretion Rats Sprague-Dawley chemistry.chemical_compound Nitrate Animals Radiology Nuclear Medicine and imaging Femur Radiation Injuries Decontamination Chelating Agents Aza Compounds Radiation Radiological and Ultrasound Technology Dose-Response Relationship Drug business.industry Radiochemistry Public Health Environmental and Occupational Health General Medicine Contamination Pentetic Acid Chelation Therapy Plutonium Rats Treatment Outcome chemistry Liver Injections Intravenous Body Burden Uranium Nuclear medicine business |
| Zdroj: | Radiation protection dosimetry. 105(1-4) |
| ISSN: | 0144-8420 |
| Popis: | The aim of this study was to compare the efficacies of DTPA, 3,4,3-LIHOPO and a newly synthesised molecule, 4,4,4-LIHOPO, in removing 233U and 238Pu after internal contamination by soluble forms of those nuclides. For this purpose, intravenous injections of DTPA (30 micromol kg(-1)) or 3,4,3-LIHOPO or 4,4,4-LIHOPO at dosages of 0.3 or 30 micromol kg(-1) were performed 1, 6 and 24 h after contamination of rats by intravenously injected 238Pu citrate and 1 h after intravenous injection of 233U nitrate. Actinide content in the main retention organs and cumulated excretion were measured 48 h after contamination. These experiments show similar decorporation efficacies of 4,4,4-LIHOPO and 3,4,3-LIHOPO for Pu, which are much higher than that of DTPA. At a dosage of 0.3 micromol kg(-1), the two LIHOPO analogues were as efficient as DTPA at a dosage of 30 micromol kg(-1). After U contamination, a 20% decorporation efficacy was obtained for either 3,4,3-LIHOPO or 4,4,4-LIHOPO at a dosage of 30 micromol kg(-1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|