Multiple Sclerosis and Obesity: Possible Roles of Adipokines
| Autor: | Lucrecia Carrera-Quintanar, Rocío Ivette López-Roa, Argelia E. Rojas-Mayorquín, A.L. Márquez-Aguirre, José de Jesús Guerrero-García, Daniel Ortuño-Sahagún |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Leptin
Diet and obesity Review Article Disease CD8-Positive T-Lymphocytes Mice 0302 clinical medicine Adipocytes Prevalence Resistin Nicotinamide Phosphoribosyltransferase Interleukin-17 Oligodendroglia Adipose Tissue Complement Factor D Adiponectin Microglia lcsh:RB1-214 Risk Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Immunology Adipokine Autoimmune Diseases 03 medical and health sciences Th2 Cells Immune system Adipokines lcsh:Pathology medicine Animals Humans Obesity Inflammation business.industry Multiple sclerosis Mesenchymal Stem Cells Cell Biology Th1 Cells medicine.disease Transplantation Disease Models Animal Astrocytes Immune System business 030217 neurology & neurosurgery 030215 immunology |
| Zdroj: | Mediators of Inflammation, Vol 2016 (2016) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue. Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development. The aim of this review was to discuss recent evidence about the link between obesity, as a chronic inflammatory state, and the pathogenesis of MS as a chronic autoimmune and inflammatory disease. First, we describe the main cells involved in MS pathogenesis, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS. Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter. Finally, we explore recent therapy that involves the transplantation of adipocyte precursor cells for the treatment of MS. |
| Databáze: | OpenAIRE |
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