Marcadores estromales en el cáncer de pulmón: la influencia de la enfermedad pulmonar obstructiva crònica
| Autor: | Rafael Aguiló, Alberto Rodríguez-Fuster, Esther Barreiro, Jun Tang, Lara Pijuan, Xavier Duran, Klara Almagro, Mercè Mateu-Jimenez, Víctor Curull, Daniel Ramis-Cabrer |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
CD31 Pathology medicine.medical_specialty Lung Neoplasms Vimentin Stroma Extracellular matrix Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Fibroblastos asociados al cáncer medicine Humans COPD Lung cancer Cancer-associated fibroblasts Cáncer de pulmón Lung biology business.industry Endothelial Cells Cancer General Medicine medicine.disease respiratory tract diseases Marcador de células endoteliales CD31 medicine.anatomical_structure 030228 respiratory system Endothelial cell marker CD31 biology.protein EPOC Matriz extracelular Estroma business Biomarkers Type I collagen |
| Zdroj: | Archivos de Bronconeumología. 57:130-137 |
| ISSN: | 0300-2896 |
| Popis: | Background Stroma, mainly composed by fibroblasts, extracellular matrix (ECM) and vessels, may play a role in tumorigenesis and cancer progression. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for LC. We hypothesized that markers of fibroblasts, ECM and endothelial cells may differ in tumors of LC patients with/without COPD. Methods Markers of cultured cancer-associated fibroblasts and normal fibroblasts [CAFs and NFs, respectively, vimentin and alpha-smooth muscle actin (SMA) markers, immunofluorescence in cultured lung fibroblasts], ECM, and endothelial cells (type I collagen and CD31 markers, respectively, immunohistochemistry) were identified in lung tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 15 LC-COPD patients and 15 LC-only patients. Results Numbers of CAFs significantly increased, while those of NFs significantly decreased in tumor samples compared to non-tumor specimens of both LC and LC-COPD patients. Endothelial cells (CD31) significantly decreased in tumor samples compared to non-tumor specimens only in LC patients. No significant differences were seen in levels of type I collagen in any samples or study groups. Conclusions Vascular endothelial marker CD31 expression was reduced in tumors of non-COPD patients, while type I collagen levels did not differ between groups. A rise in CAFs levels was detected in lung tumors of patients irrespective of airway obstruction. Low levels of CD31 may have implications in the overall survival of LC patients, especially in those without underlying airway obstruction. Identification of CD31 role as a prognostic and therapeutic biomarker in lung tumors of patients with underlying respiratory diseases warrants attention. |
| Databáze: | OpenAIRE |
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