Central nervous system effects of haloperidol on THC in healthy male volunteers
| Autor: | René S. Kahn, Ron Hijman, Marieke Liem-Moolenaar, Kari L. Franson, Daan J Touw, Joop M. A. van Gerven, Erik T. te Beek, Marieke L. de Kam |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Central Nervous System Male medicine.medical_specialty genetic structures Audiology Verbal learning Smooth pursuit Young Adult Cognition Double-Blind Method mental disorders medicine Haloperidol Humans Attention Pharmacology (medical) Dronabinol Psychiatric Status Rating Scales Pharmacology Cross-Over Studies Positive and Negative Syndrome Scale Dopamine antagonist Electroencephalography Psychotomimetic medicine.disease Pursuit Smooth Affect Psychiatry and Mental health Schizophrenia Anesthesia Hallucinogens Psychology Psychomotor Performance Antipsychotic Agents Stroop effect medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 24:1697-1708 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881109358200 |
| Popis: | In this study, the hypothesis that haloperidol would lead to an amelioration of Δ9-tetrahydrocannabinol (THC)-induced ‘psychotomimetic’ effects was investigated. In a double-blind, placebo-controlled, partial three-way crossover ascending dose study the effects of THC, haloperidol and their combination were investigated in 35 healthy, male mild cannabis users, measuring Positive and Negative Syndrome Scale, Visual Analogue Scales for alertness, mood, calmness and psychedelic effects, saccadic and smooth pursuit eye measurements, electroencephalography, Body Sway, Stroop test, Visual and Verbal Learning Task, hormone levels and pharmacokinetics. Compared with placebo, THC significantly decreased smooth pursuit, Visual Analogue Scales alertness, Stroop test performance, immediate and delayed word recall and prolactin concentrations, and significantly increased positive and general Positive and Negative Syndrome Scale score, Visual Analogue Scales feeling high, Body Sway and electroencephalography alpha. Haloperidol reversed the THC-induced positive Positive and Negative Syndrome Scale increase to levels observed with haloperidol alone, but not THC-induced ‘high’ feelings. Compared with placebo, haloperidol significantly decreased saccadic peak velocity, smooth pursuit, Visual Analogue Scales mood and immediate and delayed word recall and significantly increased Body Sway, electroencephalography theta and prolactin levels. THC-induced increases in positive Positive and Negative Syndrome Scale but not in Visual Analogue Scales feeling high were reversed by haloperidol. This indicates that psychotic-like effects induced by THC are mediated by dopaminergic systems, but that other systems are involved in ‘feeling high’. Additionally, the clear reductions of psychotic-like symptoms by a clinically relevant dose of haloperidol suggest that THC administration may be a useful pharmacological cannabinoid model for psychotic effects in healthy volunteers. |
| Databáze: | OpenAIRE |
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