Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals
| Autor: | Sonia Ammu, Kedar Narayan, Weiye Wang, Lisa M. Miller Jenkins, Miho Iijima, Paul W. Kriebel, Carole A. Parent, Ritankar Majumdar, Song Chen, Hiroshi Senoo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteome Dictyostelium discoideum Mass Spectrometry Adenylyl cyclase 03 medical and health sciences chemistry.chemical_compound Extracellular Vesicles Cell Movement Commentaries Cyclic AMP Cyclic adenosine monophosphate Secretion Dictyostelium Spotlight biology Vesicle Chemotaxis Cell Biology biology.organism_classification Cell biology 030104 developmental biology chemistry ATP-Binding Cassette Transporters Signal transduction Signal Transduction |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 |
| Popis: | Sung and Weaver discuss new work from Kriebel et al. showing how extracellular vesicles generate and sustain chemotactic signals. Directional cell motility toward a chemical gradient, chemotaxis, is critical during inflammation, embryogenesis, and cancer metastasis. In this issue, Kriebel et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201710170) demonstrate that the key cAMP chemoattractant for Dictyostelium discoideum amoebas is synthesized within and released from extracellular vesicles to promote chemotaxis. |
| Databáze: | OpenAIRE |
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