Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

Autor:	Deanne Crowell, Michael D. Tufano, Kennan C. Marsh, Kristine B. Berst, Jacob J. Plattner, Lisa A. Hasvold, Daniel T. W. Chu, Qun Li, Angela M. Nilius, Linus L. Shen, Weibo Wang, Kathleen Raye, Akiyo K. Claiborne, Jeff Alder, Robert K. Flamm
Rok vydání:	1999
Předmět:	Stereochemistry Pyridones Carboxylic acid Clinical Biochemistry Pharmaceutical Science Biological Availability Microbial Sensitivity Tests Gram-Positive Bacteria Biochemistry Chemical synthesis DNA gyrase chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Gram-Negative Bacteria Side chain Animals Molecular Biology Ternary complex Antibacterial agent chemistry.chemical_classification Bicyclic molecule Organic Chemistry Anti-Bacterial Agents Rats chemistry Lactam Molecular Medicine Half-Life
Zdroj:	Bioorganicmedicinal chemistry letters. 8(15)
ISSN:	0960-894X
Popis:	The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93775667e7384571f427311a12afcffb https://pubmed.ncbi.nlm.nih.gov/9873465 Zobrazit plný text záznamu Full Text from ScienceDirect