Percutaneous liquid ablation agent for tumor treatment and drug delivery
| Autor: | Samir Mitragotri, Hassan Albadawi, Jingjie Hu, Rahmi Oklu, Eden E. L. Tanner, Zefu Zhang, Izzet Altun, Kelly N. Ibsen, Leila Jamal |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Liver tumor medicine.medical_treatment Liver transplantation 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Doxorubicin Chemotherapy business.industry Liver Neoplasms General Medicine medicine.disease Ablation Liver Transplantation Treatment Outcome 030104 developmental biology Pharmaceutical Preparations 030220 oncology & carcinogenesis Hepatocellular carcinoma Drug delivery Cancer research Rabbits business medicine.drug Ablation zone |
| Zdroj: | Science Translational Medicine. 13 |
| ISSN: | 1946-6242 1946-6234 |
| DOI: | 10.1126/scitranslmed.abe3889 |
| Popis: | Percutaneous locoregional therapies (LRTs), such as thermal ablation, are performed to limit the progression of hepatocellular carcinoma (HCC) and offer a bridge for patients waiting for liver transplantation. However, physiological challenges related to tumor location, size, and existence of multiple lesions as well as safety concerns related to potential thermal injury to adjacent tissues may preclude the use of thermal ablation or lead to its failure. Here, we showed a successful injection of an ionic liquid into tissue under image guidance, ablation of tumors in response to the injected ionic liquid, and persistence (28 days) of coinjected chemotherapy with the ionic liquid in the ablation zone. In a rat HCC model, the rabbit VX2 liver tumor model, and 12 human resected tumors, injection of the ionic liquid led to consistent tumor ablation. Combining the ionic liquid with the chemotherapy agent, doxorubicin, resulted in synergistic cytotoxicity when tested with cultured HCC cells and uniform drug distribution throughout the ablation zone when percutaneously injected into liver tumors in the rabbit liver tumor model. Because this ionic liquid preparation is simple to use, is efficacious, and has a low cost, we propose that this new LRT may bridge more patients to liver transplantation. |
| Databáze: | OpenAIRE |
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