Relative Variability in Bioavailability of Oral Controlled-Release Formulations of Oxycodone and Morphine
| Autor: | Ruth E. Swanton, Robert D. Colucci, G. Thomas, Robert Francis Kaiko |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Adolescent Cmax Biological Availability Absorption (skin) Bioequivalence Pharmacology Reference Values Humans Medicine Pharmacology (medical) Retrospective Studies Morphine business.industry Area under the curve General Medicine Middle Aged Bioavailability Therapeutic Equivalency Controlled-Release Formulations Area Under Curve Delayed-Action Preparations business Oxycodone medicine.drug |
| Zdroj: | American Journal of Therapeutics. 8:231-236 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/00045391-200107000-00004 |
| Popis: | A retrospective analysis compared the coefficients of variation associated with the maximum plasma concentration (Cmax) and the extent of absorption (area under the curve [AUC] from 0 hour to the last observation) for oral, controlled-release tablet formulations of oxycodone (OxyContin) and morphine (MS Contin). Data from fasting, male subjects aged 18 to 45 years were taken from five controlled-release oxycodone (N = 82) and seven controlled-release morphine (N = 101) single-dose, bioequivalence studies. The coefficients of variation of Cmax and AUC were approximately 33% less for controlled-release oxycodone than for controlled-release morphine (P =.005). The variation from the minimum to maximum value was two to three times less for controlled-release oxycodone than for controlled-release morphine. Among healthy male subjects, the absorption of oxycodone from oral controlled-release oxycodone was significantly more consistent than the absorption of morphine from oral controlled-release morphine in terms of both maximum absorption and extent of absorption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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