Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides
| Autor: | William L. Matier, Barry S. Brown, Robert D. Reynolds, David M. Stout, Cynthia Barcelon-Yang |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemical Phenomena medicine.drug_class Guinea Pigs Carboxamide Parasympatholytic Structure-Activity Relationship chemistry.chemical_compound Dogs Heart Rate Ileum Drug Discovery medicine Animals Methacholine Compounds Organic chemistry Phenols Methacholine Chloride Parasympatholytic Activity Chemistry Changrolin Parasympatholytics Biological activity Amides Electric Stimulation Molecular Medicine Indicators and Reagents Anti-Arrhythmia Agents Muscle Contraction |
| Zdroj: | Journal of Medicinal Chemistry. 27:1347-1350 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00376a022 |
| Popis: | Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the amides were found to be potent antiarrhythmic agents that possessed low parasympatholytic activity. All of the compounds appear to act by a class I mechanism. |
| Databáze: | OpenAIRE |
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