Genetic causes of recurrent miscarriages
| Autor: | Marta Kacprzak, Marta Chrzanowska, Maciej Borowiec, Hanna Moczulska, Piotr Sieroszewski, Beata Skoczylas |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Abortion Habitual medicine.medical_specialty Karyotype Thrombophilia Ultrasonography Prenatal 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Prenatal Diagnosis Recurrent miscarriage medicine Humans Reproductive health Chromosome Aberrations Gynecology 030219 obstetrics & reproductive medicine Obstetrics business.industry Genetic Diseases Inborn Obstetrics and Gynecology Prenatal Care Prognosis medicine.disease Phenotype 030104 developmental biology Carrier State Carrier status Female business Maternal Age |
| Zdroj: | Ginekologia Polska. 87:722-726 |
| ISSN: | 0017-0011 |
| DOI: | 10.5603/gp.2016.0075 |
| Popis: | Recurrent miscarriage is an important problem in reproductive health, which affects 1-5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages. Knowledge of the genetic background of miscarriages is important for prognosis, as well as the potential planning of prenatal diagnostics in subsequent pregnancies. |
| Databáze: | OpenAIRE |
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