Liver-Resident Memory CD8+ T Cells: Possible Roles in Chronic HBV Infection
| Autor: | Eui-Cheol Shin, Ji Won Han |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Population Inflammation Catalysis Virus lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Cytotoxic T cell Medicine Physical and Theoretical Chemistry education lcsh:QH301-705.5 Molecular Biology Spectroscopy education.field_of_study liver-resident T cell tissue-resident T cell business.industry Organic Chemistry chronic HBV infection General Medicine cccDNA Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Immunology Hepatic stellate cell medicine.symptom business CD8 030215 immunology |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 283, p 283 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22010283 |
| Popis: | Achieving a functional cure for chronic hepatitis B virus (HBV) infection or complete elimination of HBV covalently closed circular DNA (cccDNA) has been challenging in the treatment of patients with chronic HBV infection. Although novel antivirals are being investigated, improving HBV-specific adaptive immune responses is also important for durable viral clearance. Tissue-resident memory CD8+ T (TRM) cells were recently reported as a T-cell population that resides in peripheral tissues and does not recirculate. TRM cells have been studied in the livers of mice and humans. Liver TRM cells have distinct characteristics compared to T cells in peripheral blood or other tissues, which may be associated with the unique microenvironment of the liver. In this review, we describe the characteristics of liver TRM cells and their implications in chronic HBV infection. We emphasize that liver TRM cells can be an immunotherapeutic target for the treatment of chronic HBV infection. |
| Databáze: | OpenAIRE |
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