Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Levels of b-Amyloid and Neuronal Microtubule-Associated Protein in Orthotopic Liver Transplantation Patients
| Autor: | Xueping Han, Wei Zhang, Zhen-Tao Sun, Guang Xu, Lan-Lan Li |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Tau protein tau Proteins Neuropsychological Tests law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Postoperative Complications Randomized controlled trial law Risk Factors Adrenergic alpha-2 Receptor Agonists Medicine Humans Cognitive Dysfunction Dexmedetomidine Young adult Saline Transplantation Amyloid beta-Peptides biology business.industry Incidence (epidemiology) General Medicine Middle Aged medicine.disease Liver Transplantation 030220 oncology & carcinogenesis Anesthesia biology.protein Female Transplantation Conditioning business Postoperative cognitive dysfunction 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Annals of transplantation. 21 |
| ISSN: | 2329-0358 |
| Popis: | BACKGROUND Because of the restricted data available on patients with postoperative cognitive dysfunction (POCD) in orthotopic liver transplantation (OLT), the goal of our study was to determine the outcome of dexmedetomidine (DEX) on POCD and the mechanism operating in OLT patients. MATERIAL AND METHODS Our study included 80 patients randomly divided into 2 equal groups: the DEX group and the control group. In the DEX group, our patients received an initial dose of DEX at 1 µg/kg for 10 min followed by a continuous infusion at 0.3 µg/kg/h until the end of surgery. The control group received a saline treatment, and neurological tests were performed to assess the status of POCD. Serum level of b-amyloid protein (Aβ) and neuronal microtubule-associated protein (Tau) were measured at designated time points: at pre-operation (T1), 0.5 h after the anhepatic phase (T2), 2 h after the reperfusion of the new liver (T3), at the completion of operation (T4), at day 1 (T5), and at day 7 (T6) after the operation. RESULTS The incidence of POCD was significantly reduced in the DEX group (P=0.017). The score from the neurological tests was significantly decreased in the control group after the operation, but no statistical difference was observed in the DEX group. The DEX groups demonstrated a lower level of β-amyloid and Tau protein than those at the corresponding time points (T4~T6) in the control group (P |
| Databáze: | OpenAIRE |
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