A new lipid-based oral delivery system of erythromycin for prolong sustain release activity
| Autor: | Anthony A. Attama, Franklin C. Kenechukwu, Omenigbo O. Precscila, Kenneth O. Ofokansi, Omeje E. Chidozie, Mumuni A. Momoh, Emmanuel C. Ossai, Kunle O. Olobayo |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Materials science food.ingredient Erythromycin Administration Oral Bioengineering Erythromycin Stearate 02 engineering and technology Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Beeswax Biomaterials food Drug Delivery Systems Pharmacokinetics Oral administration medicine Agar Animals Particle Size Micelles Drug Carriers Chromatography Calorimetry Differential Scanning Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Lipids 0104 chemical sciences Anti-Bacterial Agents Rats Drug Liberation Mechanics of Materials visual_art Delayed-Action Preparations Waxes visual_art.visual_art_medium Particle size 0210 nano-technology Antibacterial activity medicine.drug |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 97 |
| ISSN: | 1873-0191 |
| Popis: | Erythromycin-loaded solid lipid microparticles (SLM) based on solidified reverse micellar solution (SRMS) as an oral delivery formulation was studied. Hot homogenization technique was employed to prepare erythromycin stearate-loaded SLMs using blends of Softisan® 154 and Phospholipon® 90H or beeswax in the ratio of 1:2, and characterized in vitro. Antibacterial evaluation of the formulations was carried out by agar diffusion technique against some selected clinical isolates of bacterial. Preliminary pharmacokinetic study was performed after oral administration in male Albino rats. The results of matrix contain Softisan® 154 and phospholipon® 90H (1:2) showed that erythromycin-loaded SLM was smooth; particle size ranged from 10.3 ± 11.24 μm to 18.1 ± 10.11 μm and maximum encapsulation efficiency and loading capacity were 95.11 ± 0.3% and 43.22 ± 0.1 mg, respectively. While that of beeswax- containing matrix showed maximum particle size of 18.9 ± 21.10 μm, maximum encapsulation efficiency of 89.01 ± 0.11% and loading capacity of 39.02 ± 0.12 mg. All the formulations had prolonged release and antibacterial activity. Significantly (p > 0.05), prolonged plasma erythromycin concentration was obtained in the optimized formulation (>14 h) compared with commercial sample of erythromycin tablet (10h). Erythromycin stearate-loaded SLMs formulation could serve as an alternative to conventional oral formulation of erythromycin. |
| Databáze: | OpenAIRE |
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