Importance of Parathyroid Hormone Needle Aspiration Washout in Adenoma Localization in Primary Hyperparathyroidism
| Autor: | Şadiye Altun Tuzcu, Zafer Pekkolay |
|---|---|
| Přispěvatelé: | Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Pekkolay, Zafer |
| Rok vydání: | 2019 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Biopsy Biopsy Fine-Needle Parathyroid hormone 030204 cardiovascular system & hematology Scintigraphy Sensitivity and Specificity Parathyroid Glands 03 medical and health sciences 0302 clinical medicine Clinical Research 80 and over Needle medicine Humans Radionuclide Imaging Aged Retrospective Studies Ultrasonography Parathyroid adenoma Aged 80 and over Hyperparathyroidism Endocrine disease medicine.diagnostic_test business.industry Biopsy Needle General Medicine Middle Aged Hyperparathyroidism Primary medicine.disease Parathyroid Neoplasms Parathyroid Hormone 030220 oncology & carcinogenesis Fine-Needle Female Radiology Radiopharmaceuticals business Primary Primary hyperparathyroidism |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 3083-4899 |
| Popis: | PMD: 30834899 BACKGROUND: Primary hyperparathyroidism is an endocrine disease characterized by excessive secretion of parathyroid hormone and hypercalcemia. Although scintigraphy is commonly used for pre-operative localization, it does not always localize the parathyroid lesion. In such patients, ultrasonography can visualize the suspected lesion and needle washout sample for parathyroid hormone titer can be used to confirm parathyroid tissue. The aim of this study was to investigate the accuracy of the parathyroid hormone needle aspiration washout method in detecting the localization of parathyroid adenoma. MATERIAL AND METHODS: Patients with primary hyperparathyroidism who underwent surgery between 2010 and 2017 at the Dicle University Medical Faculty Hospital were retrospectively evaluated using medical records. Patients undergoing parathyroid hormone needle aspiration washout were performed in the suspected lesion were included in the study. Accompanied by ultrasonography, the suspected area was penetrated with needle, and negative aspiration was performed. Pre-operative scintigraphic data of patients were evaluated. Patients with positive scintigraphy, negative scintigraphy or patients who did not undergo scintigraphy were included in our study. Demographic data were presented as continuous data means ± standard deviation. Categorical variables were presented as frequency and percentage. RESULTS: Forty-nine patients (female/male, 40/9) who underwent parathyroid hormone needle aspiration washout were included in the study. Parathyroid hormone washout result was positive in 47 patients (47/49) and negative in 2 patients (2/49), sensitivity/positive predictive value (PPV) 95.91%. Twenty-six patients who had negative/suspicious scintigraphic results were diagnosed using the parathyroid hormone needle aspiration washout method (24/26, 92.3% accuracy). Parathyroid hormone needle aspiration washout without scintigraphy was performed in 13 patients (13/13, 100% accuracy). CONCLUSIONS: Parathyroid adenoma localization can be easily done using parathyroid hormone needle aspiration washout in centers experienced in adenoma localization in primary hyperparathyroidism cases in which scintigraphic results are negative or scintigraphy cannot be performed. We believe that primary parathyroid hormone needle aspiration washout can be a new localization method for adenoma localization. |
| Databáze: | OpenAIRE |
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