The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women
| Autor: | Zouhair Tabka, Amel Arfa, Ines Mrizak, Omar Šerý, Mariem Fekih, Naim Akhtar Khan, Ali Bouslema, Jiří Plesník, Monia Zaouali |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
CD36 Antigens Taste medicine.medical_specialty Tunisia Genotype CD36 Medicine (miscellaneous) Administration Oral Biology Polymorphism Single Nucleotide chemistry.chemical_compound Food Preferences Internal medicine medicine SNP Cluster Analysis Humans Obesity Allele 10. No inequality Genotyping Alleles Genetics Nutrition and Dietetics Interleukin-6 Tumor Necrosis Factor-alpha Taste Perception Middle Aged medicine.disease Taste Buds Dietary Fats Oleic acid Endocrinology chemistry biology.protein Female Oleic Acid |
| Zdroj: | The British journal of nutrition. 113(8) |
| ISSN: | 1475-2662 |
| Popis: | Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n203) using a three-alternative forced choice (3-AFC) method. Genotyping of theTNF-α(rs1800629),IL-6(rs1800795) andCD36(rs1761667) genes was performed to associate with lipid taste perception thresholds. TheCD36genotype distribution was as follows: GG (n42), AG (n102) and AA (n59). Women with theCD36GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with theCD36AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with theCD36AA genotype, but there is no significant association with theIL-6andTNF-αgene polymorphisms. |
| Databáze: | OpenAIRE |
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