An Open-Label, Parallel Group Study Investigating the Effects of Age and Gender on the Pharmacokinetics of the Once-Daily Glucagon-Like Peptide-1 Analogue Liraglutide
| Autor: | Birgitte Damholt, Poul Pedersen, Werner Wierich, Milan Zdravkovic, Marianne Ekblom, Georg Golor |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Nausea Type 2 diabetes Gastroenterology Sex Factors Pharmacokinetics Glucagon-Like Peptide 1 Internal medicine medicine Humans Hypoglycemic Agents Pharmacology (medical) Adverse effect Aged Pharmacology Liraglutide business.industry Age Factors Middle Aged medicine.disease Glucagon-like peptide-1 Confidence interval Endocrinology Vomiting Female medicine.symptom business medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 46:635-641 |
| ISSN: | 0091-2700 |
| Popis: | Liraglutide is a once-daily glucagon-like peptide-1 analogue being developed for the treatment of type 2 diabetes. The aim of this study was to investigate the effect of age and gender on the pharmacokinetics of liraglutide. Eight male and 8 female subjects were recruited from an 18- to 45-year-old group and an over-65-year-old group, respectively. All subjects received a single subcutaneous dose of 1.0 mg liraglutide. The area under the liraglutide plasma concentration curve from time 0 to last quantifiable concentration adjusted for body weight (significant covariate; P = .001) was found to be equivalent in young and elderly subjects (primary end point), with an estimated ratio of 0.94 (90% confidence interval, 0.84-1.06; P = .39). No significant impact of gender was observed (P = .38; estimated ratio, 1.08; 90% confidence interval, 0.93-1.26). Adverse events were of mild or moderate severity. The most frequently reported events were headache, vomiting, and nausea. When adjusted for body weight, no effect of gender or age was found on the pharmacokinetics of liraglutide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text