Diferencias Intra-especie en Respuesta al Estrés: Hacia Enfoques Traslacionales
| Autor: | Hugo Sánchez Castillo, Mariana Vergel-Munguía, Óscar Zamora-Arévalo, Paulina Torres-Carrillo, Diana B. Paz-Trejo, Lenin Ochoa-de la Paz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Wistar Kyoto Estrés crónico Wistar Hippocampus Amygdala SHR 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Chronic stress Prefrontal cortex business.industry General Medicine Psicología Wistar kyoto 030104 developmental biology medicine.anatomical_structure Endocrinology Cerebral cortex Hypothalamus business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Universidad Nacional Autónoma de México UNAM Redalyc-UNAM Acta de Investigación Psicológica-Psychological Research Records (México) Num.1 Vol.8 |
| ISSN: | 2007-4719 2007-4832 |
| Popis: | Stress produces the over activation of the Hypothalamus Pituitary Adrenal axis (HPA) and the neuroendocrine system. It has been shown that it could damage structures related with the emotional processing (amygdala), learning and memory (Hippocampus), decision making and prospection (prefrontal cortex). However, the stress affects are generalized without weighting all the elements related with this conditions, for example the kind of stress stimuli (acute or chronic), duration, species, etc. This allowed that some findings it will go against each other in relation to cerebral cortex function, neurochemical, hormonal and behavioral. The main porpoise of this research was to evaluate the effects of the unpredictable chronic stress on several rat strains (Wistar, Wistar Kyoto and SHR) and its immediate effects or in long term so. Wistar, Wistar Kyoto and SHR rats were used. All animals were housed in standard laboratory conditions and we follow the international guide for use and care of laboratory animals. The subjects were exposed to the Chronic Unpredictable Stress Battery (CUSB) and to evaluate the stress effects all the subjects were evaluated with a Battery of Behavioral Evaluation to find the previous, immediate or the long-term effects of CUSB exposition. The Wistar Kyoto strain showed deficits before the stress exposure. Whereas the SHR rats showed more mobility and poor attention which produces a long-term effect. The Wistar strain show a high adaptation to the adverse conditions because until the animals showed strong effects immediately after the stress exposure they showed a good recovery in the long term. In conclusion we can asseverate that the preconditions in every strain plays a major role in the stress response and that preconditions it could be used as biomarkers and in that way infer if the subjects are more susceptible to suffer high stress or some other related disease. |
| Databáze: | OpenAIRE |
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