Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
| Autor: | Olivia R. Fankuchen, Claire W. Hallahan, Anthony S. Fauci, Jana Blazkova, Kathleen R. Gittens, Jesse S. Justement, Danielle Murray, Erika Benko, Colin Kovacs, Susan Moir, Tae-Wook Chun |
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| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Disease reservoir medicine.drug_class Human immunodeficiency virus (HIV) HIV Infections Viremia HIV Antibodies Virus Replication medicine.disease_cause Monoclonal antibody Species Specificity Antiretroviral Therapy Highly Active medicine Humans Disease Reservoirs Multidisciplinary biology Virion Antibodies Monoclonal HIV virus diseases HIV envelope protein Biological Sciences medicine.disease Antibodies Neutralizing Virology Viral replication Immunology Monoclonal biology.protein Antibody |
| Zdroj: | Proceedings of the National Academy of Sciences. 111:13151-13156 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1414148111 |
| Popis: | Several highly potent and broadly neutralizing monoclonal antibodies against HIV have recently been isolated from B cells of infected individuals. However, the effects of these antibodies on the persistent viral reservoirs in HIV-infected individuals receiving antiretroviral therapy (ART) are unknown. We show that several HIV-specific monoclonal antibodies--in particular, PGT121, VRC01, and VRC03--potently inhibited entry into CD4(+) T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by ART. In addition, we demonstrate that HIV replication in autologous CD4(+) T cells derived from infected individuals receiving ART was profoundly suppressed by three aforementioned and other HIV-specific monoclonal antibodies. These findings have implications for passive immunotherapy as an approach toward controlling plasma viral rebound in patients whose ART is withdrawn. |
| Databáze: | OpenAIRE |
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