Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency
| Autor: | Shinichi Ishioka, Tasuku Mariya, Yuya Fujibe, Masahiro Yoshida, Masahito Mizuuchi, Tsuyoshi Saito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Antithrombin III Hereditary Antithrombin Deficiency lcsh:Gynecology and obstetrics Antithrombins law.invention 03 medical and health sciences 0302 clinical medicine Japan Pregnancy law medicine Humans cardiovascular diseases lcsh:RG1-991 Antithrombin III Deficiency 030219 obstetrics & reproductive medicine Obstetrics business.industry Pregnancy Complications Hematologic Antithrombin Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Venous Thromboembolism Heparin medicine.disease Recombinant Proteins Injections Intravenous Recombinant DNA Gestation Female business Venous thromboembolism Labor onset medicine.drug |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 58, Iss 6, Pp 849-851 (2019) |
| ISSN: | 1028-4559 |
| Popis: | Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. Case report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae. Conclusion: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks. Keywords: Hereditary antithrombin deficiency, Pregnancy, Prophylaxis, Recombinant human antithrombin, Venous thromboembolism |
| Databáze: | OpenAIRE |
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