Long non-coding RNA (lncRNA): A potential therapeutic target in acute lung injury
| Autor: | Syed Mansoor Ali, Almaz Zaki, Tasneem Fatma, M. Shadab Ali, Anita Chopra, Vijay Hadda |
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| Rok vydání: | 2022 |
| Předmět: |
ARDS
Lung business.industry RNA Inflammation Cell Biology respiratory system Pulmonary compliance Lung injury medicine.disease Bioinformatics Biochemistry Long non-coding RNA Pathophysiology respiratory tract diseases medicine.anatomical_structure medicine medicine.symptom business Molecular Biology Genetics (clinical) |
| Zdroj: | Genes & Diseases. 9:1258-1268 |
| ISSN: | 2352-3042 |
| Popis: | Acute Lung Injury (ALI) and its severe form Acute Respiratory Distress Syndrome (ARDS) are the major cause of ICU death worldwide. ALI/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung compliance. Despite many advances in understanding and management, ALI/ARDS is still causing significant morbidity and mortality. Long non-coding RNA (lncRNA) is a fast-growing topic in lung inflammation and injury. lncRNA is a class of non-coding RNA having a length of more than 200 nucleotides. It has been a center of research for understanding the pathophysiology of various diseases in the past few years. Multiple studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell lines. By targeting these long non-coding RNAs, many investigators have demonstrated the alleviation of ALI in various mouse models. Therefore, lncRNAs show great promise as a therapeutic target in ALI. This review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target. |
| Databáze: | OpenAIRE |
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