Recent advances in gelatin-based therapeutics
| Autor: | Raquel Hernáez-Moya, Mari Carmen Echave, Rajamani Lakshminarayanan, Gorka Orive, José Luis Pedraz, Alireza Dolatshahi-Pirouz, Leire Iturriaga, Nayere Taebnia |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Materials science food.ingredient Clinical Biochemistry Biocompatible Materials Nanotechnology Regenerative Medicine Regenerative medicine Gelatin 03 medical and health sciences 0302 clinical medicine food SDG 3 - Good Health and Well-being Tissue engineering Drug Discovery Animals Humans Pharmacology Tissue Engineering Biomaterial Biological Therapy 030104 developmental biology Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] 030220 oncology & carcinogenesis Drug delivery |
| Zdroj: | Expert Opinion on Biological Therapy, 19, 8, pp. 773-779 Echave, M C, Hernáez-Moya, R, Iturriaga, L, Pedraz, J L, Lakshminarayanan, R, Dolatshahi-Pirouz, A, Taebnia, N & Orive, G 2019, ' Recent advances in gelatin-based therapeutics ', Expert Opinion on Biological Therapy, vol. 19, no. 8, pp. 773-779 . https://doi.org/10.1080/14712598.2019.1610383 Expert Opinion on Biological Therapy, 19, 773-779 |
| ISSN: | 1471-2598 |
| DOI: | 10.1080/14712598.2019.1610383 |
| Popis: | Item does not contain fulltext INTRODUCTION: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. AREAS COVERED: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. The latter includes drug delivery systems, tissue engineering approaches, potential uses as ink for 3D/4D Bioprinting, and its relevance in organ-on-a-chip platforms. EXPERT OPINION: Advances in polymer chemistry, mechanobiology, imaging technologies, and 3D biofabrication techniques have expanded the application of gelatin in multiple biomedical research applications ranging from bone and cartilage tissue engineering, to wound healing and anti-cancer therapy. Here, we highlight the latest advances in gelatin-based approaches within the fields of biomaterial-based drug delivery and tissue engineering together with some of the most relevant challenges and limitations. 01 augustus 2019 |
| Databáze: | OpenAIRE |
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