Platelet-rich plasma regulating the repair of ultraviolet B–induced acute tissue inflammation: adjusting macrophage polarization through the activin receptor–follistatin system
| Autor: | Bingrong Zhou, Xu-Feng Yin, Yueyue Li, Yihe Chen, Wen Qian, Gajin Park, Dan Luo, Ni Zeng, Weiwei Ma, Qian Lu, Meijie Zhang, Li-wen Ma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Follistatin
Ultraviolet Rays macrophage polarization Activin Receptors Photoaging Macrophage polarization Bioengineering Inflammation Applied Microbiology and Biotechnology Skin Aging Rats Sprague-Dawley medicine Animals Skin integumentary system biology Platelet-Rich Plasma Chemistry Macrophages Regeneration (biology) activin General Medicine Activin receptor medicine.disease Rats Disease Models Animal UVB-induced acute photodamage Platelet-rich plasma biology.protein Cancer research Female medicine.symptom TP248.13-248.65 Research Article Research Paper Biotechnology |
| Zdroj: | Bioengineered article-version (VoR) Version of Record Bioengineered, Vol 12, Iss 1, Pp 3125-3136 (2021) |
| ISSN: | 2165-5987 2165-5979 |
| DOI: | 10.1080/21655979.2021.1944026 |
| Popis: | Ultraviolet B (UVB) is one of the most common exogenous factors in skin aging, especially photoaging. Once a large amount of UVB accumulates within a short period of time, skin tissue can become inflamed. It has also been found in clinics that platelet-rich plasma (PRP) can promote wound repair; therefore, the aim of this study was to identify the mechanism by which PRP repairs UVB-induced skin photodamage. We used PRP of Sprague-Dawley rats with the two-spin technique in the established acute UVB radiation photodamage model and harvested the corresponding skin after 1, 7, and 28 d. Hematoxylin and eosin staining was used to observe tissue inflammation. We found that PRP reduces inflammation in the early stages of UVB-induced acute skin damage, and then promotes the proliferation of collagen in the middle and late stages. Moreover, PRP can stimulate Act A and M1 polarization in the early stage, while inhibiting activin A (Act A) and inducing M2 polarization in the middle and late stages. In conclusion, this study demonstrates that PRP plays an important regulatory role in helping reduce UVB-induced acute skin tissue inflammation by adjusting macrophage polarization, which alleviates skin inflammation and stimulates collagen regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|