Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012-2014)
| Autor: | José Sanz, Manuel Crespo, Juan González-García, Carmen Quereda, María Ángeles Jiménez-Sousa, Ana Avellón, Salvador Resino, Josep M. Guardiola, Isabel Canorea, Ana Carrero, Víctor Hontañón, Juan Berenguer, Sonia Vázquez-Morón |
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| Přispěvatelé: | Red Española de Investigación en SIDA, Instituto de Salud Carlos III, European Regional Development Fund, Fundación para la Investigación y la Prevención del Sida en España, Ministerio de Sanidad, Servicios Sociales e Igualdad (España) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cross-sectional study viruses lcsh:Medicine HIV Infections medicine.disease_cause Gastroenterology Liver disease 0302 clinical medicine Hepatitis E virus Epidemiology Prevalence lcsh:Science Pathogen Multidisciplinary biology VIH / VHC Coinfection virus diseases Epidemiologia vírica Middle Aged Hepatitis E Hepatitis C RNA Viral Female Antibody medicine.medical_specialty Viral epidemiology 616.9 Concordance Article 03 medical and health sciences Internal medicine medicine Humans Hepatitis Antibodies business.industry Diagnosis of infectious diseases lcsh:R medicine.disease Diagnòstic de malalties infeccioses digestive system diseases 030104 developmental biology Cross-Sectional Studies Spain Immunoglobulin G biology.protein HIV / HCV HIV-1 lcsh:Q Diagnóstico de enfermedades infecciosas business 030217 neurology & neurosurgery Epidemiología vírica |
| Zdroj: | Scientific Reports r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Repisalud Instituto de Salud Carlos III (ISCIII) Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. We found a low concordance between techniques used for detection of anti-HEV antibodies (ELISA versus Immunoblot), particularly in HIV/HCV-coinfected patients. HIV/HCV-coinfected patients showed the highest prevalence of IgG against HEV, resolved hepatitis E, and exposure to HEV (19.2%, 17.2%, and 22.2% respectively). However, we did not find any samples positive for HEV-RNA nor significant differences between groups. Moreover, HIV/HCV-coinfected patients with CD4 T-cells |
| Databáze: | OpenAIRE |
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