Maxillectomy and targeted radionuclide therapy with 153Sm-EDTMP in a recurrent canine osteosarcoma
| Autor: | Ø. S. Bruland, M. Aas, M. Boysen, L. Lønaas, H. Gamlem, L. Moe |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Partial Maxillectomy
medicine.medical_specialty Targeted radionuclide therapy Canine Osteosarcoma Dogs Organophosphorus Compounds White blood cell Maxilla Organometallic Compounds medicine Animals Dog Diseases Radionuclide Imaging Small Animals Maxillary Neoplasms Radioisotopes Osteosarcoma Samarium business.industry Follow up studies medicine.disease 153sm edtmp Surgery medicine.anatomical_structure Radionuclide therapy Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1748-5827 0022-4510 |
| DOI: | 10.1111/j.1748-5827.1996.tb01782.x |
| Popis: | An eight-year-old dog with a local relapse of an osteosarcoma was treated with partial maxillectomy and systemic radionuclide therapy that involved two injections, 43 and 45 megabecquerels per kg bodyweight of the bone-seeking agent samarium-153-ethylenediaminetetramethylene phosphonic acid (153Sm-EDTMP), 15 weeks apart. A transient drop in white blood cell count and platelet count was observed following each 153Sm-EDTMP treatment. Follow-up 21 months after surgery revealed no evidence of local recurrence or metastases. The dog was in excellent condition, suffering only minor sequelae from the surgical procedure. Compared with historical controls treated with surgery alone, the combination of surgery and systemic radionuclide therapy seems a promising strategy for the treatment of canine osteosarcoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text