Female genital tract microbiota affecting the risk of preterm birth: What do we know so far? A review
| Autor: | Nikolaos Vrachnis, E. Harrison, Orestis Tsonis, K. Stefanidis, Fani Gkrozou, Minas Paschopoulos |
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| Rok vydání: | 2020 |
| Předmět: |
Female circumcision
Population Physiology Obstetric complication 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy Risk Factors Immunity Humans Medicine 030212 general & internal medicine Microbiome Pregnancy Complications Infectious education education.field_of_study 030219 obstetrics & reproductive medicine business.industry Microbiota Obstetrics and Gynecology Genitalia Female Vaginosis Bacterial General Medicine Preterm Births Neonatal morbidity Reproductive Medicine Dysbiosis Premature Birth Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 245:168-173 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2019.12.005 |
| Popis: | Spontaneous Preterm birth (SPTB) is a common obstetric complication affecting 12.9 million births worldwide and is the leading cause of neonatal morbidity and mortality. Disruption in the vaginal microbiota has an impact on the maternal immunological profile leading to SPTBs. Scientists have struggled to link maternal infectious agents with the dysregulation of the maternal immune response in cases of SPTBs. Throughout the last decade, important findings regarding the role of microbiota and its genome, the so-called microbiome, have linked alterations within the population of the microorganisms in our bodies with changes in nutrition, immunity, behaviour and diseases. In this review, evidence regarding the female genital tract microbiota and microbiome has been examined to help further our understanding of its role in disrupting the maternal immune system resulting in spontaneous preterm birth. |
| Databáze: | OpenAIRE |
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