Pediatric uveitis secondary to probable, presumed, and biopsy-proven sarcoidosis
| Autor: | Howard H. Tessler, Frederick Oh, Daniel E. Choi, Andrea D. Birnbaum, Debra A. Goldstein |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Eye Diseases Sarcoidosis Biopsy Peptidyl-Dipeptidase A Uveitis Periphlebitis medicine Humans Child medicine.diagnostic_test business.industry Medical record Pediatric uveitis General Medicine medicine.disease Dermatology Ophthalmology Child Preschool Pediatrics Perinatology and Child Health Referral center Female Muramidase business Ocular sarcoidosis |
| Zdroj: | Journal of pediatric ophthalmology and strabismus. 48(3) |
| ISSN: | 1938-2405 |
| Popis: | Purpose: To describe pediatric patients with uveitis diagnosed as having sarcoidosis. Methods: Medical records of pediatric patients evaluated between 1987 and 2008 were reviewed to identify those with ocular inflammation in whom a diagnosis of sarcoidosis was considered. A classification system including ocular findings and results of laboratory testing was devised and used to classify likelihood of sarcoidosis. Results: Four hundred sixty children younger than 17 years were evaluated. Based on the classification system designed, 13 patients (2.8%) had probable, presumed, or definite sarcoidosis. The mean age was 11.6 years (range: 5 to 16 years). Elevated angiotensin-converting enzyme was measured in 6 patients and lysozyme in 5 patients. Five of 12 patients in whom chest imaging was performed had signs of sarcoidosis. Anterior segment involvement was non-granulomatous more often than granulomatous. Seven patients had multifocal choroiditis and 4 patients had retinal periphlebitis. Conclusion: Ocular sarcoidosis is uncommon in children, even at a tertiary referral center. Pulmonary involvement was detected in slightly less than half of the patients who had imaging, in contrast to previous reports of almost universal lung involvement in children 8 to 15 years old. The classification system of presumed, probable, and definite sarcoidosis presented may be useful in clinical practice. |
| Databáze: | OpenAIRE |
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