Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis: a prospective cohort study

Autor: Marius Henriksen, A. Bennett, Else Marie Bartels, Robin Christensen, Pia Christensen, Henning Bliddal, Henrik Gudbergsen, Morten Ilum Boesen
Rok vydání: 2014
Předmět:
Male
Weight loss
Time Factors
Knee Joint
Osteoarthritis
Urine
Cartilage Oligomeric Matrix Protein
Gastroenterology
Body Mass Index
chemistry.chemical_compound
Orthopedics and Sports Medicine
Prospective Studies
Prospective cohort study
CTX-I
Osteoarthritis
Knee
Middle Aged
Weight Reduction Programs
Treatment Outcome
Creatinine
Female
medicine.symptom
medicine.medical_specialty
Biomedical Engineering
Rheumatology
N-terminal telopeptide
Weight Reduction Programs/methods
Internal medicine
medicine
Humans
Knee
Cartilage Oligomeric Matrix Protein/blood
Obesity
CTX-II
Collagen Type II
Rank correlation
business.industry
COMP
Creatinine/blood
medicine.disease
Surgery
Obesity/blood
Osteoarthritis
Knee/blood
chemistry
Collagen Type II/blood
Weight Loss/physiology
business
Body mass index
Biomarkers
Biomarkers/blood
Follow-Up Studies
Zdroj: Bartels, E M, Christensen, R, Christensen, P, Henriksen, M, Bennett, A, Gudbergsen, H, Boesen, M & Bliddal, H 2014, ' Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis: a prospective cohort study ', Osteoarthritis and Cartilage, vol. 22, no. 11, pp. 1817-1825 . https://doi.org/10.1016/j.joca.2014.07.027
Bartels, E M, Christensen, R, Christensen, P, Henriksen, M, Bennett, A, Gudbergsen, H, Boesen, M & Bliddal, H 2014, ' Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis : A prospective cohort study ', Osteoarthritis and Cartilage, vol. 22, no. 11, pp. 1817–1825 . https://doi.org/10.1016/j.joca.2014.07.027
ISSN: 1063-4584
DOI: 10.1016/j.joca.2014.07.027
Popis: Objective: Changes in biomarkers for bone and cartilage in knee osteoarthritis (KOA) may reflect changes in tissue turnover induced by interventions. The aim of this study was to assess the effect on osteoarthritis biomarkers of an intensive weight loss intervention in obese KOA patients. Methods: 192 obese KOA patients followed a 16 weeks weight loss intervention (ClinicalTrials.gov: NCT00655941). Serum Cartilage Oligomeric Matrix Protein (sCOMP), Urine C-terminal telopeptide of collagen type II (uCTX-II) and type I (uCTX-I) were determined by enzyme-linked immunoassay (ELISA) at baseline and after 16 weeks. Patient-reported symptoms were assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire without the sports and recreation score (KOOS-4). Change from baseline was analyzed using Analysis of CoVariance (ANCOVA) adjusting for sex, age, and body mass index (BMI). Bivariate associations were analyzed using Spearman's test of rank correlation. Results: 175 patients completed the treatment and lost mean 13.4 (95% CI: 12.5-14.4) kg. sCOMP concentration decreased on average 1.1 (95% CI: -1.5 to -0.8) U/L with a correlation to weight loss (r = -0.17, P = 0.028), but not to change in KOOS-4 (r = -0.13, P = 0.091). uCTX-II increased significantly, mean 69 (95% CI: 31-106)ng/mmol creatinine, with no relation to weight loss (P = 0.14). Change in uCTX-II was reversely related to change in KOOS-4 (r = -0.28, P = 0.0003). uCTX- I increased, mean 67 (95% CI: 47-87) mu g/mmol creatinine, and correlated to weight loss (r = 0.22, P = 0.0007), while not to KOOS-4 (P = 0.93). Conclusion: A rapid substantial weight loss in obese KOA patients was weakly, while significantly associated with a reduction in sCOMP, and increases in both uCTX-II and uCTX-I. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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