Sperm DNA fragmentation negatively influences the cumulative live birth rate in the intracytoplasmic sperm injection cycles of couples with unexplained infertility

Autor:	Deepthi Repalle, K.V. Saritha, Shilpa Bhandari
Rok vydání:	2022
Předmět:	Reproductive Medicine
Zdroj:	Clinical and Experimental Reproductive Medicine. 49:185-195
ISSN:	2233-8241 2233-8233
DOI:	10.5653/cerm.2021.05169
Popis:	Objective: This study aimed to determine the effect of sperm DNA fragmentation (SDF) on the cumulative live birth rate (CLBR) in intracytoplasmic sperm injection (ICSI) cycles in couples with unexplained infertility.Methods: We conducted a prospective study of 145 couples who underwent ICSI cycles for unexplained infertility. Based on the SDF rate, patients were categorized into a low SDF group (SDF ≤30%, n=97) and a high SDF group (SDF >30%, n=48). SDF was assessed using the acridine orange test on density gradient centrifugation prepared samples. The CLBR was calculated as the first live birth event per woman per egg collection over 2 years.Results: The high SDF group (SDF >30%) showed a significantly lower CLBR (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9363ab3a1b1effe7f956ee7d13fb4a2d https://doi.org/10.5653/cerm.2021.05169 Zobrazit plný text záznamu Plný text ve formátu PDF