An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis
| Autor: | Juan E. Corral-Hurtado, Ly Elaine Pham, Surakit Pungpapong, Andrew P. Keaveny, Omar Y. Mousa, Andree Koop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Vitamin
Liver Cirrhosis medicine.medical_specialty Cirrhosis Nutritional Status Specialties of internal medicine Gastroenterology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound Liver disease 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Vitamin A deficiency Vitamin D and neurology Medicine Humans 030212 general & internal medicine Vitamin D Vitamin A Vitamin D deficiency Zinc deficiency Hepatology business.industry General Medicine medicine.disease Prognosis Malnutrition Zinc chemistry RC581-951 030211 gastroenterology & hepatology business Biomarkers |
| Zdroj: | Annals of Hepatology, Vol 17, Iss 6, Pp 920-932 (2018) |
| ISSN: | 1665-2681 |
| Popis: | Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. This is a narrative review including the relevant literature for cirrhosis and vitamin D, vitamin A, and zinc deficiencies. Vitamin D deficiency has important effects in cirrhosis, regardless of the cause of chronic liver disease.These effects include associations with fibrosis and outcomes such as infections, hepatocellular carcinoma, and mortality. Vitamin A deficiency is associated with liver disease progression to cirrhosis and clinical decompensation, including occurrence of ascites or hepatic encephalopathy. Zinc deficiency can lead to hepatic encephalopathy and impaired immune function. Such deficiencies correlate with patient survival and disease severity. Caution should be applied when replacing vitamin D, vitamin A, and zinc to avoid toxicity. Identification and appropriate treatment of vitamin and mineral deficiencies in cirrhosis may reduce specific nutritional and cirrhosis-related adverse events. Routine monitoring of vitamin A, vitamin D and zinc levels in cirrhosis should be considered. |
| Databáze: | OpenAIRE |
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