Growth Hormone Induces Low-Density Lipoprotein Clearance but not Bile Acid Synthesis in Humans
| Autor: | Lars Berglund, Birgit Borgström, Gösta Eggertsen, S. Ericsson, Hans Olivecrona, Suzanne Lind, Mats Rudling, Bo Angelin, Mats Eriksson |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty medicine.drug_class medicine.medical_treatment Familial hypercholesterolemia Drug Administration Schedule Hypopituitarism Bile Acids and Salts Hyperlipoproteinemia Type II Insulin-like growth factor chemistry.chemical_compound Internal medicine Atorvastatin medicine Humans Pyrroles Child Dose-Response Relationship Drug Bile acid biology Human Growth Hormone Cholesterol Cholesterol LDL Lipoprotein(a) Middle Aged medicine.disease Lipoproteins LDL Endocrinology chemistry Heptanoic Acids Low-density lipoprotein Colestipol LDL receptor biology.protein Drug Therapy Combination Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 24:349-356 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000110657.67317.90 |
| Popis: | Objective— Growth hormone (GH) induces hepatic low-density lipoprotein (LDL) receptors and lowers plasma cholesterol. We characterized the influence of GH treatment on plasma LDL clearance in normal humans and investigated the relative role of LDL receptor (LDLR) activity and stimulation of bile acid synthesis in subjects with different LDLR expression. Methods and Results— Plasma clearance of autologous 125 I-LDL was measured before and during 3 weeks of treatment with GH (0.1 IU/kg per day) in 9 healthy young males. Plasma LDL cholesterol was reduced by 13% and the fractional catabolic rate of LDL increased by 27%. More marked changes were seen in a patient with hypopituitarism substituted with GH (0.07 IU/kg per day) for 3 months. In a second study, GH dose-dependently reduced LDL cholesterol and increased Lp(a) levels in 3 groups of males: younger and elderly healthy subjects and heterozygous familial hypercholesterolemia (FH). No effect on bile acid synthesis measured by the plasma marker 7α-hydroxy-4-cholesten-3-one was observed. In an LDLR-deficient FH homozygote, LDL cholesterol was not affected by GH. Conclusions— GH treatment reduces plasma LDL cholesterol by inducing LDL clearance. In humans, LDLR expression is a prerequisite for this effect, whereas it is not related to stimulation of bile acid synthesis. |
| Databáze: | OpenAIRE |
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