A deltamethrin crystal polymorph for more effective malaria control
| Autor: | Bart Kahr, Chunhua Hu, Isis Paola Carmona-Sepúlveda, Jingxiang Yang, Ethan Reiter, Michael D. Ward, Xiaolong Zhu, Bryan Erriah, Vilmalí López-Mejías |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Insecticides
Mosquito Control 030231 tropical medicine Indoor residual spraying Biology Models Biological Insecticide Resistance Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malaria transmission Anopheles Nitriles Pyrethrins parasitic diseases medicine Pyrethroid resistance Animals Humans 030304 developmental biology 0303 health sciences Multidisciplinary Pyrethroid medicine.disease Malaria Drosophila melanogaster Deltamethrin chemistry Insecticide resistance Physical Sciences Female Crystallization Malaria control |
| Zdroj: | Proc Natl Acad Sci U S A |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Pyrethroid contact insecticides are mainstays of malaria control, but their efficacies are declining due to widespread insecticide resistance in Anopheles mosquito populations, a major public health challenge. Several strategies have been proposed to overcome this challenge, including insecticides with new modes of action. New insecticides, however, can be expensive to implement in low-income countries. Here, we report a simple and inexpensive method to improve the efficacy of deltamethrin, the most active and most commonly used pyrethroid, by more than 10 times against Anopheles mosquitoes. Upon heating for only a few minutes, the commercially available deltamethrin crystals, form I, melt and crystallize upon cooling into a polymorph, form II, which is much faster acting against fruit flies and mosquitoes. Epidemiological modeling suggests that the use of form II in indoor residual spraying in place of form I would significantly suppress malaria transmission, even in the presence of high levels of resistance. The simple preparation of form II, coupled with its kinetic stability and markedly higher efficacy, argues that form II can provide a powerful, timely, and affordable malaria control solution for low-income countries that are losing protection in the face of worldwide pyrethroid resistance. |
| Databáze: | OpenAIRE |
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